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FDA grants priority review to Roche's Tecentriq in combination with chemotherapy for the initial treatment of extensive-stage small cell lung cancer

F. Hoffmann-La Roche Ltd /
FDA grants priority review to Roche's Tecentriq in combination with chemotherapy
for the initial treatment of extensive-stage small cell lung cancer
. Processed and transmitted by West Corporation.
The issuer is solely responsible for the content of this announcement.

Basel, 05 December - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the
US Food and Drug Administration (FDA) has accepted the company's supplemental
Biologics License Application (sBLA) and granted Priority Review for Tecentriq®
(atezolizumab), in combination with carboplatin and etoposide (chemotherapy),
for the initial (first-line) treatment of people with extensive-stage small cell
lung cancer (ES - SCLC). The FDA is expected to make a decision on approval by
18 March 2019. A Priority Review designation is granted to medicines that the
FDA has determined to have the potential to provide significant improvements in
the treatment, prevention or diagnosis of a serious disease.

"It's been more than 20 years since there has been a new initial treatment
option for extensive-stage small cell lung cancer that delivers a clinically
meaningful survival benefit," said Sandra Horning, MD, Chief Medical Officer and
Head of Global Product Development. "We are working closely with the FDA to
bring this Tecentriq-based regimen to people with this difficult-to-treat type
of lung cancer as soon as possible."

This sBLA is based on results from the Phase III IMpower133 study, which met its
co-primary endpoints of overall survival (OS) and progression-free survival
(PFS) in the initial treatment of people with ES-SCLC. The safety profile of the
combination was consistent with the safety profiles of the individual medicines,
and no new safety signals were identified.

Tecentriq is currently approved by the FDA to treat people with metastatic non-
small cell lung cancer (NSCLC) who have disease progression during or following
platinum-containing chemotherapy, and have progressed on an appropriate FDA-
approved targeted therapy if their tumour has ALK or EGFR gene abnormalities.

About the IMpower133 study
IMpower133 is a Phase III, multicentre, double-blinded, randomised placebo-
controlled study evaluating the efficacy and safety of Tecentriq in combination
with carboplatin and etoposide versus chemotherapy (carboplatin plus etoposide)
alone in chemotherapy-naïve people with ES-SCLC. The study enrolled 403 people
who were randomised equally (1:1) to receive:

* Tecentriq in combination with carboplatin and etoposide (Arm A), or
* Placebo in combination with carboplatin and etoposide (Arm B, control arm)

During the treatment-induction phase, people received treatment on 21-day cycles
for four cycles, followed by maintenance with Tecentriq or placebo until
progressive disease (PD) as assessed by the investigator using Response
Evaluation Criteria in Solid Tumours Version 1.1 (RECIST v1.1). Treatment could
be continued until persistent radiographic PD or symptomatic deterioration was

The co-primary endpoints were:

* PFS as determined by the investigator using RECIST v1.1 in the intention-to-
treat (ITT) population
* OS in the ITT population

IMpower133 met its OS and PFS co-primary endpoints as per the study protocol.
The analysis showed that Tecentriq and chemotherapy helped people live
significantly longer, compared with chemotherapy alone (OS=12.3 versus 10.3
months; hazard ratio [HR]=0.70; 95% CI: 0.54-0.91; p=0.0069) in the ITT
population. [1] The 1-year OS rate for people who received the Tecentriq-based
combination was 51.7%, compared with 38.2% for people who received chemotherapy
alone. The Tecentriq-based combination also significantly reduced the risk of
disease worsening or death (PFS) compared with chemotherapy alone (PFS=5.2
versus 4.3 months; HR=0.77; 95% CI: 0.62-0.96; p=0.017).[1] The 1-year PFS rate
for people who received the Tecentriq-based combination was 12.6%, compared with
5.4% for people who received chemotherapy alone. Safety for the Tecentriq and
chemotherapy combination appeared to be consistent with the known safety profile
of the individual medicines, and no new safety signals were identified with the

Grade 3-4 treatment-related adverse events (AEs) were reported in 56.6% of
people receiving Tecentriq plus chemotherapy, compared with 56.1% of people
receiving chemotherapy alone. [1]

About SCLC
Lung cancer is the leading cause of cancer death globally.[2] Each year 1.76
million people die as a result of the disease; this translates into more than
4,800 deaths worldwide every day. [2] Lung cancer can be broadly divided into
two major types: non-small cell lung cancer (NSCLC) and SCLC, with SCLC
accounting for approximately 15% of all lung cancer cases. [3] Survival rates
for people with SCLC vary depending on the stage (extent) of the cancer at the
time of diagnosis. [4] The five-year relative survival rate for people with
stage I SCLC is approximately 31%; however, at stage IV, the five-year relative
survival rate declines to approximately 2%.[5]

About Tecentriq
Tecentriq is a monoclonal antibody designed to bind with a protein called PD-L1
expressed on tumour cells and tumour-infiltrating immune cells, blocking its
interactions with both PD-1 and B7.1 receptors. By inhibiting PD-L1, Tecentriq
may enable the activation of T cells. Tecentriq has the potential to be used as
a foundational combination partner with cancer immunotherapies, targeted
medicines and various chemotherapies across a broad range of cancers.

Currently, Roche has nine Phase III lung cancer studies underway, evaluating
Tecentriq alone or in combination with other medicines.

Tecentriq is already approved in the European Union, United States and more than
80 countries for people with previously treated metastatic NSCLC and for certain
types of untreated or previously treated metastatic urothelial carcinoma (mUC).

About Roche in cancer immunotherapy
For more than 50 years, Roche has been developing medicines with the goal to
redefine treatment in oncology. Today, we're investing more than ever in our
effort to bring innovative treatment options that help a person's own immune
system fight cancer.

By applying our seminal research in immune tumour profiling within the framework
of the Roche-devised cancer immunity cycle, we are accelerating and expanding
the transformative benefits with Tecentriq to a greater number of people living
with cancer. Our cancer immunotherapy development programme takes a
comprehensive approach in pursuing the goal of restoring cancer immunity to
improve outcomes for patients.

To learn more about the Roche approach to cancer immunotherapy please follow
this link:

About Roche
Roche is a global pioneer in pharmaceuticals and diagnostics focused on
advancing science to improve people's lives. The combined strengths of
pharmaceuticals and diagnostics under one roof have made Roche the leader in
personalised healthcare - a strategy that aims to fit the right treatment to
each patient in the best way possible.

Roche is the world's largest biotech company, with truly differentiated
medicines in oncology, immunology, infectious diseases, ophthalmology and
diseases of the central nervous system. Roche is also the world leader in in
vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in
diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose
and treat diseases and make a sustainable contribution to society. The company
also aims to improve patient access to medical innovations by working with all
relevant stakeholders. Thirty medicines developed by Roche are included in the
World Health Organization Model Lists of Essential Medicines, among them life-
saving antibiotics, antimalarials and cancer medicines. Moreover, for the tenth
consecutive year, Roche has been recognised as the most sustainable company in
the Pharmaceuticals Industry by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100
countries and in 2017 employed about 94,000 people worldwide. In 2017, Roche
invested CHF 10.4 billion in R&D and posted sales of CHF 53.3 billion.
Genentech, in the United States, is a wholly owned member of the Roche Group.
Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more
information, please visit www.roche.com.

All trademarks used or mentioned in this release are protected by law.

[1] Horn L et al. First-line atezolizumab plus chemotherapy in extensive-stage
small-cell lung cancer. N Engl J Med. 2018; DOI: 10.1056/NEJMoa1809064.
[2] World Health Organization. GLOBOCAN 2018; Lung Cancer: Estimated cancer
incidence, mortality and prevalence worldwide. [Internet]:
Accessed December 2018.
[3] Alvarado-Luna G and Morales-Espinosa D. Treatment for small cell lung
cancer, where are we now? - a review. Transl Lung Cancer Res. 2016;5(1):26-38.
[4] American Cancer Society; Key Statistics for Small Cell Lung Cancer
[Internet]: https://www.cancer.org/cancer/small-cell-lung-cancer/about/key-
statistics.html. Accessed December 2018.
[5] American Cancer Society; Small Cell Lung Cancer Survival Rates, by Stage
[Internet]: https://www.cancer.org/cancer/small-cell-lung-cancer/detection-
diagnosis-staging/survival-rates.html. Accessed December 2018.

Roche Group Media Relations
Phone: +41 61 688 8888 / e-mail: media.relations@roche.com
- Nicolas Dunant (Head)
- Patrick Barth
- Ulrike Engels-Lange
- Simone Oeschger
- Anja von Treskow


This announcement is distributed by West Corporation on behalf of West Corporation clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: F. Hoffmann-La Roche Ltd via GlobeNewswire

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