Micromet Shows Feasibility of Subcutaneous Delivery of BiTE Antibody in Preclinical Primate Study

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BETHESDA, MD, April 14, 2008 -- Micromet, Inc. (Nasdaq: MITI), a
biopharmaceutical company developing novel, proprietary antibodies
for the treatment of cancer, inflammation and autoimmune diseases,
presented data at the annual meeting of the American Association for
Cancer Research (AACR) in San Diego, CA, showing good bioavailability
and predictable serum levels of subcutaneously administered BiTE®
antibodies (1). BiTE antibodies are designed to direct the body's
cytotoxic, or cell-destroying, T cells against tumor cells, and
represent a new therapeutic approach to cancer therapy.

Micromet conducted a pharmacokinetic study in non-human primates
exploring different routes of administration of its BiTE antibody
MT110, which is targeting EpCAM (CD326) and is the most advanced BiTE
antibody with potential application for the treatment of solid
tumors. Continuous intravenous administration, as currently used in
an ongoing phase 1 clinical trial with MT103 (MEDI-538), was compared
to subcutaneous administration by daily repeated bolus injection and
continuous administration using mini-pumps, which are commercially
available and routinely used by patients with diabetes for the
delivery of insulin. Both subcutaneous regimens resulted in
bioavailability of MT110 of 30 to 40 percent, with constant serum
trough levels over the six-day treatment period.

"Our pre-clinical results are paving the way for the development of
alternative routes of administration for MT110 and other BiTE
antibodies to further enhance the quality of life of patients under
treatment," comments Patrick A. Baeuerle, Micromet's chief scientific
officer. "A very convenient mini-pump system, designed for life-long
use by diabetes patients for insulin delivery, may become an
attractive alternative to repeated subcutaneous injection."

Reference

1. Schlereth, B. et al. Feasibility of Repeated Subcutaneous
Delivery Establishes a New Route of Administration for Treating
Cancer Patients with EpCAM-specific BiTE Antibody MT110. Annual
Meeting of AACR, San Diego, 2008, Abstract No. 2403.

(more)

About BiTE Antibodies

BiTE® antibodies are designed to direct the body's cytotoxic, or
cell- destroying, T cells against tumor cells, and represent a new
therapeutic approach to cancer therapy. BiTE antibodies have been
shown to induce an immunological synapse between a T cell and a tumor
cell in the same manner as observed during physiological T cell
attacks. These cytolytic synapses enable the delivery of cytotoxic
proteins from T cells into tumor cells, ultimately inducing a
self-destruction process in the tumor cell referred to as apoptosis,
or programmed cell death. In the presence of BiTE antibodies, T cells
have been demonstrated to serially eliminate tumor cells, which
explains the activity of BiTE antibodies at very low concentrations
and at very low ratios of T cells to target cells. Through the
process of killing cancer cells, T cells proliferate, which leads to
an increased number of T cells at the site of attack.

Several antibodies in Micromet's product pipeline are BiTE antibodies
and have been generated based on Micromet's proprietary BiTE antibody
platform. The most advanced BiTE antibody is MT103 (MEDI-538),
targeting CD19, and has provided proof-of-concept in an ongoing phase
1 clinical study in patients with advanced non-Hodgkin's lymphoma.
MT110, which is targeting EpCAM (CD326) and is the first BiTE
antibody with potential applications in the treatment of solid
tumors, has completed preclinical development. Two additional BiTE
antibodies, targeting CEA and MCSP, are in preclinical development.

About Micromet, Inc. (www.micromet-inc.com)

Micromet, Inc. is a biopharmaceutical company developing novel,
proprietary antibodies for the treatment of cancer, inflammation and
autoimmune diseases. Three of its antibodies are currently in
clinical trials, while the remainder of the product pipeline is in
preclinical development. The BiTE® antibody MT103 is in a phase 2
clinical trial for the treatment of patients with acute lymphoblastic
leukemia and in a phase 1 clinical trial for the treatment of
patients with non-Hodgkin's lymphoma. BiTE antibodies represent a new
class of antibodies that activate a patient's own cytotoxic T cells,
considered the most powerful "killer cells" of the human immune
system, to eliminate cancer cells. Micromet is developing MT103 in
collaboration with MedImmune, Inc., a subsidiary of AstraZeneca plc.
The second clinical stage antibody is adecatumumab, also known as
MT201, a human monoclonal antibody which targets epithelial cell
adhesion molecule (EpCAM)-expressing solid tumors. Micromet is
developing adecatumumab in collaboration with Merck Serono in a phase
1b clinical trial evaluating adecatumumab in combination with
docetaxel for the treatment of patients with metastatic breast
cancer. The third clinical stage antibody,

(more)

MT293 is licensed to TRACON Pharmaceuticals, Inc. and is being
developed in a phase 1 clinical trial for the treatment of patients
with cancer. In addition, Micromet has established a collaboration
with Nycomed for the development and commercialization of MT203, a
human antibody neutralizing the activity of granulocyte/macrophage
colony stimulating factor (GM-CSF), which has potential applications
in the treatment of various inflammatory and autoimmune diseases,
such as rheumatoid arthritis, psoriasis, or multiple sclerosis.

Forward-Looking Statements

This release contains certain forward-looking statements that involve
risks and uncertainties that could cause actual results to be
materially different from historical results or from any future
results expressed or implied by such forward-looking statements.
Factors that may cause actual results to differ materially from any
future results expressed or implied by any forward-looking statements
include the risk that product candidates that appeared promising in
early research, preclinical studies or clinical trials do not
demonstrate safety and/or efficacy in subsequent clinical trials, the
risk that encouraging results from early research, preclinical
studies or clinical trials may not be confirmed upon further analysis
of the detailed results of such research, preclinical study or
clinical trial, the risk that additional information relating to the
safety, efficacy or tolerability of our product candidates may be
discovered upon further analysis of preclinical or clinical trial
data, the risk that we or our collaborators will not obtain approval
to market our product candidates, the risks associated with reliance
on outside financing to meet capital requirements, and the risks
associated with reliance on collaborators, including MedImmune, Merck
Serono, TRACON and Nycomed, for the funding or conduct of further
development and commercialization activities relating to our product
candidates. You are urged to consider statements that include the
words "ongoing," "may," "will," "would," "could," "should,"
"believes," "estimates," "projects," "potential," "expects,"
"suggests," "plans," "anticipates," "intends," "continues,"
"forecast," "designed," "goal," or the negative of those words or
other comparable words to be uncertain and forward-looking. These
factors and others are more fully discussed in our periodic reports
and other filings with the SEC.

Any forward-looking statements are made pursuant to Section 27A of
the Securities Act of 1933, as amended, and Section 21E of the
Securities Exchange Act of 1934, as amended, and, as such, speak only
as of the date made. Micromet, Inc. undertakes no obligation to
publicly update any forward-looking statements, whether as a result
of new information, future events or otherwise.

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Contact Information

Media: Investors:
Andrea tenBroek/Chris Stamm Susan Noonan
(781)-684-0770 (212) 966-3650
micromet@schwartz-pr.com susan@sanoonan.com

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Micromet Inc.
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